Category: MIL-OSI

Source: The Conversation – Africa – By Tawanda Zininga, Lecturer and Researcher, Stellenbosch University

Malaria remains one of the world’s most devastating infectious diseases, claiming more than half a million lives each year. In Africa, the illness is mostly caused by a parasite carried by mosquitoes – Plasmodium falciparum.

When the parasite invades the human body, it faces a hostile environment: soaring fevers, attacks from the body’s immune system, and the stress of antimalarial medicines. Yet it can survive, thanks to an internal defence system made up of “helper” molecules known as heat shock proteins.

Among these, a powerful group called small heat shock proteins act as the parasite’s last line of defence. These molecules behave like tiny bodyguards, protecting other proteins inside the parasite from damage when conditions become extreme. They are the parasite’s emergency rescue team when energy reserves are dangerously low, such as during high fever or exposure to drugs.

In my biochemistry laboratory, we’re looking for ways to disrupt these bodyguards.

Master’s student Francisca Magum Timothy and I are using advanced protein-chemistry tools to examine three small heat shock proteins found in the parasite. These share a common core structure but behave differently.

We’ve found that they can be chemically disrupted. This marks an exciting direction for malaria research. Instead of directly killing the parasite, the approach focuses on disarming its defences, allowing other treatments or the body’s immune system to finish the job.

The next steps involve finding small, drug-like molecules that can specifically target and disable these parasite proteins without harming human cells. This will require advanced computer modelling, laboratory testing and eventually, studies in animal models to make sure the approach is both effective and safe. If successful, this could lead to a new class of antimalarial drugs that work in a completely different way from current treatments. This is an especially important goal as resistance to existing medicines continues to grow.

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Read more: Malaria scorecard: battles have been won and advances made, but the war isn’t over

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From early laboratory work to developing a drug that could be tested in people will likely take around eight to 10 years, depending on how the candidates perform in each research stage. Still, the discovery of these heat shock protein targets represents a big step forward and offers real hope for more effective, long-lasting malaria control in the future.

Unpacking the mysteries of three proteins

We found clear differences between the three proteins we tested in the laboratory.

One was the strongest and most stable of the trio, the other was more flexible but less stable, and one was the weakest protector.

When tested in stress conditions, all three acted as “molecular sponges”, preventing other proteins from clumping together. That’s a crucial step for the parasite’s survival during fever. But their protective strength varied: one offered the most consistent defence, while the other lost structure more easily.

These findings suggest that the parasite may rely on a team effort among the three, each taking on a slightly different role during stress.

So we asked: could natural compounds found in plants disrupt these bodyguards? Our team focused on quercetin, a plant-based flavonoid. Flavonoids are among the compounds that give plants their bright colours, like red in apples, purple in berries, or yellow in lemons. They help protect plants from sunlight, pests and disease. These are abundant in apples, onions and berries. Quercetin is already known for its antioxidant and anti-inflammatory properties. Some studies have already hinted that it might slow down malaria parasites.

When we exposed the parasite proteins to quercetin, we observed remarkable effects. The compound destabilised the small heat shock proteins, altering their shape and reducing their ability to protect other proteins. In simple terms, quercetin appeared to confuse or weaken the parasite’s bodyguards.

Further tests confirmed that quercetin also slowed the growth of malaria parasites in laboratory cultures. When malaria parasites were grown in controlled laboratory conditions and exposed to quercetin, they multiplied more slowly than usual, including strains that are resistant to standard drugs. This is encouraging because it suggests that quercetin itself, or new medicines made to work like it but even more strongly, could become the starting point for developing a new type of antimalarial drug in the future.

Moreover, small heat shock proteins kick in when the parasite’s energy supply, known as ATP, the cell’s main “fuel”, runs very low. In simple terms, when the parasite is close to running out of energy and facing danger, these proteins act as its last line of defence.

Next steps

Our findings point to the possibility of drugs being designed that shut down these ATP-independent helpers and strike the parasite precisely when it is weakest.

Although quercetin itself is a natural compound found in many foods, its potency and stability are not yet strong enough for clinical use. The team envisions chemical modification of quercetin’s structure to create derivatives with enhanced activity and better drug-like properties.

As global efforts to eliminate malaria face growing challenges from drug resistance, innovations like this provide renewed hope. By turning the parasite’s own survival machinery against it, scientists may have found a subtle but powerful way to outsmart one of humanity’s oldest foes.

– Taking down malaria’s bodyguards: scientists target parasite’s secret defence system
– https://theconversation.com/taking-down-malarias-bodyguards-scientists-target-parasites-secret-defence-system-267029

Source: The Conversation – Africa – By Abotebuno Akolgo, Postdoctoral Fellow, Bard College Berlin; Bayreuth University

Bank lending is a major source of funding for businesses in Ghana. It helps pay for operational expenditure and investment in expansion of productive capacity. Therefore, it is important that there is substantial, affordable, and accessible financial credit for all businesses in the medium to long term. More than this, it matters which sectors of the country’s economy receive most of its bank credit.

In a recent study of the sectoral distribution of bank lending in Ghana, I found that for two and a half decades, bank lending to the agricultural and manufacturing enterprises has been in sharp decline.

In the 25 years from 1999 to 2023, the share of total bank credit that went to the agricultural and manufacturing sector fell by about 65% and 56% respectively. For instance, in 1999, about 25% of total bank lending went to manufacturing businesses. By 2023 however, that figure had fallen to about 11%.

I am an economist with expertise in the political economy of money, finance, and development in Africa. My research on Ghana has attempted to explain the financial constraints to the country’s economic transformation since independence in 1957. I have previously written on Ghana’s sovereign indebtedness and its banking and monetary policies.

The findings in the current study matter because in Ghana, agriculture and manufacturing are crucial to creating substantial, sustainable, and shared economic growth. Agriculture is the second largest employer in Ghana’s economy after the services sector. It is also crucial for creating the raw materials that can fuel manufacturing sector growth.

The role of banks & finance in economic development

There is no single perspective among economists on how banks operate or should operate in an economy. There are those economists within neoclassical economics circles who hold the conventional, largely discredited view that banks act merely as intermediaries who take money from savers and lend to borrowers.

In contrast, there are those, particularly post-Keynesian economists, who assert, rightly, that modern banks do not merely receive deposits and turn them into loans. They insist that banks create credit for borrowers but not necessarily from savers’ deposits.

Still, most economists agree on some things. First of all, that finance is crucial to economic development. Secondly, that the banking system has a role in the flow of finance to individuals, households and businesses.

Not all forms of financial flows are healthy for economic transformation, however. The key then for successful financial policy is to distinguish between productive and unproductive credit.

Productive credit flows support the entrepreneurial innovation that is central to creating new products or expanding production levels. This kind of credit will for instance support agricultural production and expand manufacturing capacity and outputs.

Unproductive credit does not increase the level of output. For instance, lending to support household consumption or financial speculation is unproductive.

The Ghanaian banking system does not generate enough credit for the private sector. However, that was hardly the concern for this study. Of particular interest is the question: where does the credit go to?

Bank credit to agriculture and manufacturing has declined

My study set out to disaggregate the data on financial credit to the various sectors of the Ghanaian economy. These sectors included agriculture, manufacturing and services. The evidence shows that bank lending has not significantly supported real productive sectors such as agriculture and manufacturing.

As indicated in Figures 1 and 2, the shares of financial credit to the agricultural and manufacturing have been in decline. On average, over the last 25 years, 14.6% and 5.8% of total bank credit was allocated to manufacturing and agriculture respectively. In contrast, the services sector averaged 20.7% of bank credit. Commerce and finance sector received an average of 17.3% over the same period.

As productive sectors are denied sufficient credit, well-paid and sustainable jobs cannot be created in agriculture or manufacturing as most Ghanaians are reduced to informal petty trading of foreign goods.

Two main reasons have accounted for this dysfunction of the financial system. First, the foreign domination of Ghana’s banking sector, and second the failure of monetary policy. About 50% of banks in Ghana are foreign owned. Foreign banks tend to be more risk averse. They are less likely to lend to small and medium-scale enterprises (SMEs).

Second, the Bank of Ghana’s excessive focus on monetary stability through inflation-targeting is problematic. It often results in raising interest rates and, consequently, borrowing costs. This discourages private sector borrowing while attracting bank investments into government securities. Ghana’s inflation is largely driven by structural factors and not money supply problems. These factors include production and transport costs. Monetary stability through inflation-targeting is therefore a misplaced priority.

Besides, by focusing solely on monetary stability, the central bank is neglecting its role to support the overall development of the economy through credit policy. This developmental role is clearly set out in The Bank of Ghana (Amendment) Act 2016 (Act 918). This revised the 2002 Act to take account of the central bank’s role to support government economic policy and ensure an efficient operation of the banking and credit system.

Before the IMF-led financial reforms of the 1980s and 1990s which were necessitated by the 1980s financial crisis, the Bank of Ghana intervened, effectively and efficiently, to direct credit to priority sectors. For instance, in the early 1980s when the liberal financial reforms had not taken root in Ghana, the Bank of Ghana used a combination of credit ceilings, interest rates, reserve requirements, and mandatory lending ratios to direct credit to agriculture and industry. Credit ceilings ensured that banks could not lend beyond a certain limit to sectors other than agriculture and manufacturing. Lower interest rates were also offered to agricultural loans and in other instances, mandatory lending ratios ensured banks were forced to lend a certain share of loans to agriculture and manufacturing.

Drawing lessons from the present moment and past, I recommend a serious rethink of financial policy. A return to some level of credit policies, a deliberate support for indigenous participation in the banking system and a revitalisation of development banks such as the Agricultural Development Bank and the National Investment Bank.

– Ghana’s banks are not lending enough to sectors where it matters most, like agriculture and manufacturing
– https://theconversation.com/ghanas-banks-are-not-lending-enough-to-sectors-where-it-matters-most-like-agriculture-and-manufacturing-265433

Source: The Conversation – Africa – By Tanya Zack, Visiting senior lecturer, University of the Witwatersrand

Since its founding in 1886, Johannesburg, has been a city of migrants, internal and international. But the economic capital of South Africa has undergone big changes since 1994 when South Africa became a democracy. One such change involves migration into the city by people from other African countries.

A new book, The Chaos Precinct: Johannesburg as a port city, by Tanya Zack traces how migrant Ethiopians have shaped a trading post in Johannesburg’s inner city. Zack, a planner who specialises in urban policy, regeneration, informality and sustainable development, explains how the Ethiopians did it.

What space have Ethiopian migrants carved out in the centre of Johannesburg?

The book is set in the shopping centres of the so-called Ethiopian Quarter, in high-rise, formerly commercial buildings in the inner city of Johannesburg. It is a cross-border shopping hub of thousands of cupboard-sized shops crammed into buildings. It defies the categories of formal or informal, of wholesale or retail. And it is where people from all of southern Africa come to shop for fast fashion.

While migrants from several countries trade here, the trading post was pioneered by and remains dominated by Ethiopian and Eritrean migrants. It is an extraordinary shopping district in what were high-rise medical buildings. These office towers centre on Rahima Moosa (previously Jeppe) Street, where medical practitioners and pharmaceutical companies once agglomerated.

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Buildings that had been underutilised or abandoned became the canvas for an entrepreneurial transformation. Ethiopian migrants led the repurposing of these structures into over 3,000 tiny shops. Shopfronts are linked to storerooms located higher up in the buildings or nearby spaces. This new retail footprint wasn’t known in Johannesburg three decades ago. And the scale of trading has attracted many infrastructure uses that support the transnational movement of goods and people.

It was not supported by formal planning or pension funds, but developed by migrant entrepreneurs, one shop at a time.

They draw on global supply chains, particularly Chinese wholesalers operating in warehouse-style malls west of the inner city, to access a steady stream of fast fashion, cosmetics and household items. Inner-city-based Ethiopian traders then retail these goods in individual or smaller quantities. Their clientele is composed largely of cross-border traders who on-sell the products throughout southern Africa.

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Read more: How migrant entrepreneurs are a force for good in South Africa

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This model has effectively turned the inner city into an inland port. It’s a logistics hub where goods circulate rapidly, and where shoppers are embedded in an informal yet highly organised distribution network.

The inner-city street grid, first surveyed in 1886 during Johannesburg’s mining camp era, consists of very short blocks, which amplify pedestrian and vehicular congestion. It’s a frenzied shopping environment.

Shopkeepers and stallholders have maximised their display areas through creative lightweight architectures. Small shopfronts are linked to storerooms higher up in buildings or nearby. Sidewalks are lined with street vendors, forming mini corridors.

Internal arcades in the buildings further maximise the retail footprint. This hybrid, vertically integrated structuring has generated a real estate boom in previously underutilised buildings in a flagging property market.

The success of this enclave is also tied to the migrants’ ability to craft both social and commercial networks. Migrant traders and cross-border shoppers have relationships based on trading through information sharing, mutual assistance, and informal credit mechanisms. Traders are necessarily adaptive. They adjust to the pace of demand, shifting product lines quickly. They also coordinate closely with suppliers and resellers throughout Southern Africa. The spaces they use and adapt are similarly flexible.

This combination of adaptive reuse, dense retail specialisation and networked entrepreneurship has allowed Ethiopian migrants to carve out a commercial territory that is at once highly visible and deeply embedded in regional trade flows.

South Africa has been harsh towards informal economic activity. How has this been managed?

The Ethiopian Quarter exists in a context of often-hostile municipal and national governance.

South Africa has historically oscillated between tolerance and repression of informal economic activity, particularly when driven by foreign migrants. Law enforcement campaigns have regularly targeted street traders and migrant shopkeepers. Traders and shoppers alike face the constant threat of violent policing, corruption, theft, and harassment. Uniformed police or wardens regularly confront them, demanding that they prove their migrant status. There’s talk of being detained in vehicles until a bribe is paid.

Ethiopian migrant traders have developed a range of strategies to navigate the challenges of hostility. They co-locate with other Ethiopian traders, and rely on ethnic and commercial networks to absorb shocks and share information about law enforcement activities.

Ethiopian traders have also innovatively adapted their physical and commercial operations to reduce vulnerability. Shops are designed to control stock and display goods while concealing cash and high-value items. The light architectures and arcade designs of Jeppe also make it possible to conceal the shop in the event of raids.

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Read more: Johannesburg fire disaster: why eradicating hijacked buildings is not the answer

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Shoppers spend as little time as possible inside the crime-ridden Johannesburg CBD. On the day they choose goods, they often carry no money. They return later with cash to purchase goods as swiftly as possible so that cash is not carried unnecessarily. Many hide cash on their bodies.

The infrastructures that have developed to service the port-like functions of this massive cross border trading hub offer storage, package, information exchange and distribution services. Hotels, buses and storage facilities provide relative safety for cross-border shoppers who must navigate a city known for crime. A 2017 survey, funded by the Johannesburg Inner City Partnership, found that over 60% of retailers had experienced physical assault. 38% reported regularly giving police officers something to mitigate harassment.

What lessons do you draw about how cities should govern migration?

The cross-border shopping hub demonstrates that migrant-driven informal economies are engines of economic activity. Estimates based on the 2017 cross border shopping survey showed that shoppers in the Jeppe district alone spent close to US$600 million annually. This was twice the turnover of Sandton City, at that time Africa’s richest mall.

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The activities of Jeppe mimic international entrepots like Singapore and Hong Kong. They offer information exchange, repackaging and distribution services for goods flowing from China to international destinations. This Johannesburg entrepot has regional significance, distributing goods throughout southern Africa. But it’s under-recognised by municipal authorities.

A law and order approach must at least be coupled with a developmental approach. Cities that aim to govern migration must integrate migrant economic activity rather than suppress it.

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Read more: Africa without borders could help the continent prosper – what’s getting in the way

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Support through infrastructure improvements and security provision would amplify Jeppe’s economic impact.

This includes recognising the legitimacy of informal trading spaces, investing in basic infrastructure and safety, and developing regulations that protect safety while accommodating new building uses.

Partnership approaches that involve traders’ associations, building managers and community intermediaries to co-manage spaces would be valuable.

What does your work tell us about a city that’s been in decline. And solutions?

The burgeoning economy in Jeppe needs to be recognised alongside the private investments in Johannesburg that are celebrated for their regenerative capacity. This migrant enclave demonstrates how urban regeneration can evolve out of the actions of thousands of actors.

The challenge is to direct, support and harness this energy.

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Read more: Cities are central to our future – they have the power to make, or break, society’s advances

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If we were to think of Johannesburg as a port, how would we understand and use the ecosystems of trade, movement and distribution that this networked economy has created? What other services could flow through these ecosystems? And what safety, mobility and public infrastructure services are required to enhance these entrepot functions and claim this role for the city, an African urban hub tied to multiple cities and small towns across the continent?

The cross-border shopping hub of Jeppe offers hope for an inland entrepot to be recognised, supported and expanded to offer the global services that Johannesburg’s infrastructure can provide.

– Ethiopian quarter: how migrants have shaped a thriving shopping district in South Africa’s city of gold
– https://theconversation.com/ethiopian-quarter-how-migrants-have-shaped-a-thriving-shopping-district-in-south-africas-city-of-gold-266494